What are ingredients of Waklert and Artvigil?
Waklert and Artvigil are Indian brand names for armodafinil, a chemical that can make you feel more concentrated and alert. Armodafinil has a chemical structure that is similar to those of modafinil, another wakefulness-promoting drug. However, while armodafinil is an R-enantiomer, modafinil is an R- and S-enantiomer, making its chemical properties slightly different from those of armodafinil. Armodafinil is a white powder that can be easily dissolved in methanol. Water and acetone are less suitable for dissolving armodafinil.
Both Hab Pharma Artvigil and Sun Pharma Waklert comes in pill form and is to be taken orally. You can buy Waklert and Artvigil in following dosages: 50mg, 150mg. Armodafinil is the main ingredient for both Waklert and Artvigil. The additional (inactive) ingredients of Waklert and Artvigil include lactose, starch, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate.
As of today, healthcare experts are unable to provide an exact explanation of how both armodafinil and modafinil promote wakefulness and alertness. The main ingredients for both armodafinil (waklert, Artvigil) and modafinil (modvigil, modalert) are supposed to have similar mechanisms of action because of how similar their pharmacological properties discovered in non-clinical and in-vitro studies are.
If taken in recommended dosages, armodafinil is incapable of inhibiting receptors and enzymes that are known to regulate a person’s sleep cycles, such as serotonin, melatonin, dopamine, melanocortin, or benzodiazepines. In addition, armodafinil does not bind to transporters for a number of important brain chemicals, such as phosphodiesterase VI, GABA transaminase, and norepinephrine. Modafinil displays similar chemical properties when it comes to most receptors and enzymes.
However, both drugs are capable of interacting with dopamine transporters, binding to them and temporarily inhibiting the reuptake of the chemical. In vivo animal studies have shown that modafinil is capable of increasing extracellular levels of dopamine in certain brain regions. Exposing genetically engineered mice that lack the DAT (a dedicated dopamine transporter) to modafinil has had no effect on the sleep cycles of affected mice. This suggests that modafinil is dependent on the DAT to provide its beneficial effects. At the same time, the effects of modafinil were discovered to be unaffected by haloperidol, a DAT antagonist.
Similar studies conducted with amphetamines and haloperidol have shown that the latter has a powerful antagonizing effect on the former. What’s more, the same results were observed in studies focusing on alpha-methyl-p tyrosine and amphetamines, while modafinil remains unaffected by alpha-methyl-p tyrosine and other chemicals that inhibit dopamine synthesis. This suggests that both armodafinil and modafinil have different methods of action as compared to amphetamines and other sympathomimetic agents despite providing very similar pharmacological effects.
Modafinil can not only promote wakefulness and temporarily boost locomotor activity (as observed in non-clinical animal studies), but also have a profound impact on the user’s mood, ranging from short-term euphoric effects to noticeable changes in the usual thinking patterns and perception. This is typical of most other medications that stimulate the central nervous system. Long-term use of modafinil exposes the user to the medication’s powerful reinforcing properties, which were first observed in monkeys that chose to self-administer modafinil just like they did with cocaine.